In this study, we have shown that a peptide (MBCP) obtained from gastrointestinal digestion of Mozzarella of Bufala Campana DOP is able to modulate the differentiation and permeability in Caco-2 cells stimulated with TNF-α and to attenuate inflammation and hypermotility in murine models of intestinal inflammation. The gene discussed is TNF; the disease is gastroenteritis.