C5AR2 and cancer: Among them, we can find markers of mesenchymal origin, such as αSMA or cell surface proteins associated with crucial biological functions of CAF, like fibroblast activation protein (FAP), which enzymatically remodel ECM and induce cancer cells migration [29], CD10, a zinc-dependent metalloproteinase [30], or G protein-coupled receptor 77 (GPR77), which activates VEGF expression and angiogenesis in hypoxic breast TME [31].