In this case, the query contained the user-defined gene list as GLS2, GPR39, PTPRN2, GHRL, GHSR, MBOAT4, CPT1A, JUN, TP53, PGLS, and GPT2. Unlike GLS, the alterations in the GLS2-centered-signature-gene occur mainly in lung cancer. The gene discussed is PGLS; the disease is lung cancer.