Intra-articular injections of recombinant (rh) IL-37 or adenovirus encoding human IL-37 in mice with collagen-induced [88] or streptococcal cell wall (SCW)-induced arthritis [89] drive the downregulation of locally produced IL-17 and other Th17-related cytokines and ameliorate arthritic symptoms. Here, IL37 is linked to Arthritis.