AKT1 and herpes simplex infectious disease: Figure 4 illustrates this result indicating a PI3K-Akt signaling pathway, cytokine–cytokine receptor interaction, the nucleotide-binding oligomerization domain (NOD)-like receptor, Jak-STAT, retinoic acid-inducible gene (RIG)-I-like receptor signaling pathways, Toll-like receptor pathway and pathways involved in HPV, herpes simplex and hepatitis infection were the most significantly represented in terms of the number of genes identified by GISTIC.