Figure 4 illustrates this result indicating a PI3K-Akt signaling pathway, cytokine–cytokine receptor interaction, the nucleotide-binding oligomerization domain (NOD)-like receptor, Jak-STAT, retinoic acid-inducible gene (RIG)-I-like receptor signaling pathways, Toll-like receptor pathway and pathways involved in HPV, herpes simplex and hepatitis infection were the most significantly represented in terms of the number of genes identified by GISTIC. Here, SOAT1 is linked to herpes simplex infectious disease.