During the acute phase of sepsis (i.e., the first seven days in patients), lymphocytes—T cells in particular—upregulate the inhibitory receptors cytotoxic T lymphocyte antigen-4 (CTLA4), T cell immunoglobulin mucin-3 (TIM-3), lymphocyte activation gene 3 (LAG-3), or interleukin-7 (IL-7) receptor [6]. The gene discussed is HAVCR2; the disease is Sepsis.