For the first time, we have studied potential interactions between SIRT2 (rs10410544) variants and APOE genotypes in AD patients (N = 1086; 625 Females (57.55%), age: 71.26 ± 9.47 years, range: 50–98 years, and 461 males (42.45%), age: 70.79 ± 9.81 years, range: 50–97 years). The gene discussed is SIRT2; the disease is Alzheimer disease.