In the present paper, we report for the first time the genophenotype of patients associated with sirtuin 2 variants (rs10410544) and interactions with the apolipoprotein E (APOE) gene, the most relevant pathogenic risk factor for dementia, and with the CYP2D6 gene, the most influential metabolic gene in AD pharmacogenetics [2,3,4,6,19]. Here, SIRT2 is linked to Alzheimer disease.