Given our most recently have identified that the TET1/USP28/CD44/RhoGDIβ pathway that is crucial for ATG7′s oncogenic role in human BC cell invasion, metastasis and stem-like properties [20], our findings reveal that PD-L1 was the important upstream regulator for ATG7-induced human BC sphere formation and tumorigenesis. This evidence concerns the gene CD274 and breast cancer.