Ectopic expression GFP-PD-L1 in T24T(shATG7#1) cells promoted the conversion of LC3 from LC3-I to LC3-II, inhibited AUF1 and increased RhoGDIβ protein expression (Figure 7A), revealing PD-L1 was the critical upstream factor for ATG7-induced human BC invasion. This evidence concerns the gene CD274 and breast cancer.