Sulforaphane, an active constituent present in broccoli and cauliflower, exhibits a potent effect against several cancers, including cervical, bladder, prostate, and renal cell carcinoma, by hitting various signaling networks, such as the STAT3/HIF-1α/VEGF and Nrf2 signaling pathways [139]. The gene discussed is HIF1A; the disease is hereditary clear cell renal cell carcinoma.