Identification is essentially dependent on the expression analysis of a number of selected biomarkers, including the autophagy relevant microtubule-associated proteins 1A/1B light chain (MAP1LC3B), Beclin-1 (BECN1), autophagy related 5 (ATG5), and B-cell lymphoma 2 (BCL-2) genes, as well as others whose expression levels in CRC biopsy sections are used as a surrogate for the active autophagy [94]. Here, ATG5 is linked to colorectal carcinoma.