In contrast to nontreated con cells, for senescent human breast cancer MDA-MB-231 cells, the factors detected by arrays and secreted at a significant level are FGF-6, GM-CSF, IGFBP-1, MCP-1, IL-6, IL-1α, GRO a/b/g, GRO α, IL-8, MIP, MIP-1α, uPAR, ICAM-1, and MMP-1(Figure 2). The gene discussed is MMP1; the disease is breast cancer.