TNF and obesity due to melanocortin 4 receptor deficiency: Reductions in NF-κB and pro-inflammatory cytokines, such as Tnf-α and Mcp-1, as well as increases in anti-inflammatory cytokines, such as Il-10, are unsurprising since n-3 PUFAs are well-established anti-inflammatory agents [63]; however, reporting improvements in inflammation independent of obesity is noteworthy.