Determining complex genomic alterations and rearrangements in SCLC, which are undetectable by the existing gene analysis technologies, might further contribute to understanding of SCLC occurrence; therefore, performing whole-genome sequencing is necessary; one of the hallmarks of SCLC is the high frequency of mutations in TP53 and RB1 [75,76]. Here, TP53 is linked to small cell lung carcinoma.