Through a chemical library screen, oncrasin-1 (oncogenic Ras tumor-inhibiting compound 1) showed synthetic lethality for KRAS and protein kinase C iota (PKCi) [53], and phenformin, a mitochondrial inhibitor and analog of the diabetes therapeutic metformin, induced apoptosis in LKB1-deficient NSCLC cells [54]. Here, PRKCI is linked to diabetes mellitus.