Lipopolysaccharide (LPS) can interact with Toll-like receptor 4 (TLR4), leading to the activation of nuclear transcription factor-kappa B (NF-κB), a transcription factor that plays an important role in both inflammation and cancer [56,57,58,59,60,61,62,63,64,65,66,67]. The gene discussed is TLR4; the disease is cancer.