Importantly, it has been reported that, with regard to perimenopausal endometriosis, endometrioid ovarian carcinomas (ENOC) and clear cell ovarian carcinomas (CCOC) are associated with mutations of ARID1A, a tumor suppressor gene [30], PTEN, KRAS and -catenin (CTNNB1) genes [31]. Here, PTEN is linked to ovarian clear cell cancer.