All VZV-infected monocytes, NK cells, NKT cells, B cells, CD4+ T cells, CD8+ T cells and HFLs showed nuclear VZV ORF63 expression indicative of productive infection (Fig 2A) that was not observed with isotype control stains (Fig 2B), while uninfected PBMCs and HFLs showed no ORF63 expression as expected (Fig 2C). This evidence concerns the gene CD4 and infection.