CD33 and cancer: In particular, granulocyte-type CD15(high) CD33(low) cells and monocyte-type CD15(low) CD33(high) cells were found in BC tissue and produced substantial amounts of proinflammatory chemokines, and interfere with cancer cells as well as with the T-cell system, thereby regulating the invasive potential of cancer cells and the functional efficiency of the local immune response [20].