Here, we show that in NB cell line, XN inhibited the Akt activation as evidenced by the reduction in phosphorylation of AKT ser 473 and its downstream target Cyclin D1, TNF-related apoptosis-inducing ligand (TRAIL) is a cytokine that induces apoptosis via binding to death receptor 5 (DR5) [24]. The gene discussed is TNFRSF10B; the disease is neuroblastoma.