INS and metabolic dysfunction-associated steatotic liver disease: We detected the fatty liver dystrophy, vacuolar degeneration of hepatocytes and the increased expression of factors responsible for inflammation and apoptosis in the liver of obese agouti-mice, which indicates the metabolic dysregulations in the hepatocytes and, along with the insulin and leptin resistance is considered as an important mechanism of triggering the non-alcoholic fatty liver disease [64–66].