LEP and metabolic syndrome: In our study, it was first shown that the 10-day treatment of agouti-mice with melanocortin-type obesity with MF at the doses ranging from 200 to 600 mg/kg/day led to the decrease in the body and fat weight, food intake, dyslipidemia, hyperinsulinaemia and hyperleptinemia and to the restoration of the intrahypothalamic levels of leptin and insulin, and these effects were dose-dependent.