Compared with normal controls, the abundance of COG samples in SLE patients had significantly increased fimbrial protein (COG3539), chaperone (COG3121), outer membrane usher protein (COG3188), glutathione stransferase (COG0625), monooxygenase (COG2141) and dehydrogenase (COG2133), but decreased transposase(COG3666), solute binding protein-like protein(COG3889), endo-beta-n-acetylglucosaminidase (COG4724), fibronectin type III domain protein(COG3401), carboxylesterase (ec 3.1.1.1) (COG1647) and nucleotidyl transferase (COG1213). This evidence concerns the gene ENGASE and systemic lupus erythematosus.