Recently, down‐regulation of TSPAN1 expression markedly blocks GC cell proliferation, cell‐cycle progression and invasive activity in gastric cancer.27 However, it is observed opposite effect that TSPAN1 control cell migration in prostate cancer.21, 28 These reports confirmed that TSPAN1 participate cell migration and invasion in some human cancer, meantime, indicating TSPAN1 may be involved in complex signalling pathway and dependent‐tissue specificity. The gene discussed is TSPAN1; the disease is cancer.