The most famous examples are the Ras proto‐oncogenes HRas, KRas and NRas, which are mutated in circa 25 % of cancers.6 Whilst these small GTPases have been extensively studied, other superfamily members are also linked to disease, including cancer, neurodegenerative, and autoimmune diseases.7 Disorders can arise from abnormal regulatory activity; for example, overexpression or mutations of GEFs, GAPs, or GDIs are linked to several forms of cancer and neurodegenerative diseases.8 This evidence concerns the gene HRAS and cancer.