RAPGEF4 and pancreatic neoplasm: ESI‐09 (26, Figure 12) inhibited cAMP‐mediated Epac1 and 2 GEF activities with IC50 values of 11 μm and 4.4 μm, respectively.56 Molecular docking predicted binding to a single CNBD domain in both proteins.5726 was used to show that Epac proteins have a role in the migration of pancreatic cancer cells, and in vivo significantly reduced pancreatic cancer cell invasion and metathesis.57, 58