In the development of esophageal cancer, a variety of signaling pathways are involved, among which Wnt/β‐catenin signaling pathway is one of the most classical oncogenic signaling pathways.14 Its overactivation can promote the expression of target gene c‐myc and cyclin D1 which in turn to promote the proliferation, migration, and invasion of tumor cells. The gene discussed is CCND1; the disease is esophageal cancer.