LiCl is often used as an inhibitor of GSK3β which promotes GSK3β phosphorylation and inactivation.16 We found that knockdown of SPINK5 in esophageal cancer cells has a similar effect to LiCl and upregulates the expression level of p‐GSK3β (S9) (Figure 5A). The gene discussed is SPINK5; the disease is esophageal cancer.