The cytoplasmic CK1, AXIN, APC, GSK3β, and other proteins form a degradation complex, which promotes the phosphorylation of the ser33 and ser37 of β‐catenin by binding to β‐catenin protein, which leads to the ubiquitination degradation of β‐catenin.15 In previous studies, we found that overexpression of SPINK5 in esophageal cancer cells inhibited the expression of p‐GSK3β (S9), whereas knockdown of SPINK5 upregulated the expression of p‐GSK3β (S9), suggesting that SPINK5 can affect the activity of GSK3β. This evidence concerns the gene SPINK5 and esophageal cancer.