SPINK5 and esophageal cancer: In esophageal cancer cells, we overexpressed β‐catenin (GFP‐β‐catenin) in combination with protease inhibitor MG132, the results showed that MG132 significantly upregulated the expression of GFP‐β‐catenin and reversed the overexpression of SPINK5 to inhibit GFP‐β‐catenin (Figure 5D).