Moreover, 80 protein isoforms encoded by 73 differential IR genes have significant reduction in their expression (orange line, Figure 5h and Supporting Information Figure S6c), whereas 41 IR genes show increased protein level (48 protein isoforms, green line, Figure 5h and Supporting Information Figure S6c) in AD tissues when compared to control frontal cortex (p < 0.05, LIMMA t test) (Supporting Information Table S10). This evidence concerns the gene INSR and Alzheimer disease.