CD8A and neoplasm: However, in the presence of HLA class 1 expression, patients with a tumor that was strongly infiltrated with CD8+ T-cells displayed a survival benefit, whereas in the absence or downregulation of HLA class 1 expression, this effect was lost (p for interaction 0.01; hazard ratio 0.41, 95% CI 0.15–1.10, p = 0.08 and hazard ratio 7.67, 95% CI 0.88–66.4, p = 0.07, respectively) (Figs. 3, 4).