IL-33 has a single domain that binds to its receptor, IL-1 receptor like 1 (IL1RL1), also known as suppression of tumorigenicity 2 (ST2), and eliminates intestinal parasite infections through the induction of Th2 cytokines, such as IL-13 and IL-5 [18–21]. The gene discussed is IL1RL1; the disease is parasitic intestinal disorder.