This study aimed at assessing the effects of the SMF generated by the magnetic closure of the optimized prototype of a recently developed miniaturized bioreactor (Laganà and Raimondi 2012) on the metabolic activity, viability and gene expression of target genes (Hsp-70, Bcl-2 and Bax) in human SH-SY5Y neuroblastoma cells. The gene discussed is BAX; the disease is neuroblastoma.