The DAA combination of glecaprevir (NS3/4A protease inhibitor developed by AbbVie and Enanta) and pibrentasvir (NS5A inhibitor), co-formulated as the once-daily, pangenotypic regimen of glecaprevir/pibrentasvir (G/P), was recently approved for patients with chronic HCV GT1-6 infection including those with compensated cirrhosis, chronic kidney disease (CKD), and prior DAA failure in Japan and overseas. Here, KRAS is linked to chronic kidney disease.