Previous study demonstrated that prometastasis genes such as MYC 7, 8 and RAS 9 facilitate osteosarcoma metastasis and metastasis‐resistant genes including nm23 10, p16 11 and KiSS‐1 metastasis‐suppressor 12 inhibited the metastasis process in osteosarcoma. Here, NME1 is linked to osteosarcoma.