JUN and colorectal carcinoma: 21 reported that knockdown of YAP1 in breast cell lines suppressed anoikis, increased migration, and invasiveness and enhanced tumor growth in nude mice. Barry et al. 22 demonstrated that YAP1 is significant silenced in a highly aggressive and undifferentiated human colorectal carcinoma, and that its expression can restrict the growth of colorectal carcinoma xenografts. YAP1 is also an important component of c‐Jun‐mediated apoptosis 23.