Prenatally, diagnosis can be made via chorionic villus sampling and amniocentesis; postnatally, the sickling test (determines carrier status), Hb electrophoresis, high-performance liquid chromatography (HPLC), isoelectric focusing (IEF), and DNA analysis can be used to diagnose SCD. The gene discussed is GSTM1; the disease is Schnyder corneal dystrophy.