We managed a GSEA by using GBM patient gene profiling data (GSE53733), and showed in Fig. 5, gene set differences in SAA1 in low versus high glioma patients indicated that SAA1 regulates biology process mainly associated with inflammatory response processes (P < 0.001 FDR = 0.012) and cytokine mediated signaling pathway (P < 0.001 FDR = 0.012) (Figs. 5I and 5J). This evidence concerns the gene SAA1 and central nervous system cancer.