Elevated levels of SAA1 in the serum of cancer patients directly correlate with poor prognosis and tumor aggressiveness in various types of cancer, including lung cancer (Cho et al., 2010), cell renal carcinoma (Kosari et al., 2005), melanomas (Findeisen et al., 2009) and so on. This evidence concerns the gene SAA1 and hereditary clear cell renal cell carcinoma.