Some studies have shown that EE has significant benefits in animal models of neurodegenerative diseases, including AD [29–32]; long-term or short-term exposure to EE can improve synaptic plasticity [33, 34] and thus mitigate cognitive deficits [32, 33]; EE can reduce amyloid deposition and tau hyperphosphorylation [32]. This evidence concerns the gene MAPT and Cognitive impairment.