Ranked by q-value (lowest q-value first), the ten most commonly mutated genes in our collection of KIT-mutant GIST were KIT, SF3A2, RB1, FRG1, NFAM1, GRB14, APLF, CELA1, YY1AP1, and ZYX (Fig. 1b). The gene discussed is APLF; the disease is gastrointestinal stromal tumor.