CASP8 and neoplasm: The candidate tumor suppressor genes were separately significant in tumor group and normal group except IKZF1, CASP5 and CASP8, which significantly indicate that PPM1A, DAPK1 and FBP1 were hypermethylation in tumor samples, at the same time, PYH1N1, ALPL and SMCHD1 were hypermethylation in normal samples.