MSH2 and pancreatic neoplasm: Furthermore, individuals of Ashkenazi Jewish (AJ) heritage represent a genetically distinct population,24–27 which is characterised by higher prevalence of germline mutations in BRCA1, BRCA2, MSH2, and MSH6,28–30 and higher incidence of various malignancies including pancreatic cancer.31–35 The National Comprehensive Cancer Network (NCCN) guidelines recommend genetic counselling for AJ individuals diagnosed with pancreatic cancer.36 Yet, the association of family history with risk of pancreatic cancer is not well defined in the context of religious heritage.