FLNC promotes prostate cancer progression by enhancing the migratory capacity of tumour cells.27 FLNC was upregulated in hepatocellular carcinoma cells as compared to normal liver cells, and its overexpression induced cell migration; additionally, FLNC knockdown suppressed cell proliferation and migration while enhancing apoptosis, whereas FLNC overexpression enhanced cancer progression and metastasis both in vitro and in vivo.26,29 High FLNC expression was also related to poor prognosis in patients. This evidence concerns the gene FLNC and Familial prostate cancer.