CDC42 and glioblastoma: FLNC knockdown in oesophageal squamous cell carcinoma cell lines reduced GTP-Rac1 and GTP-Cdc42 levels, thereby altering cell motility.28 However, in GBM cells, FLNC overexpression affected invasion but not migration, and there was no obvious change in Rho activity (Supplementary Fig. S6A).