FLNC and neoplasm: The ability to remodel the ECM is important for tumour cell invasion and dissemination; indeed, the metastatic potential of GBM cells can be enhanced by increasing their motility and/or ability to degrade ECM.6,7,49 Our GSEA of TCGA data revealed a significant enrichment of gene signatures associated with lamellipodia, focal adhesion, and invadopodia and also metastatic features, suggesting that FLNC promotes the malignant characteristics of GBM (Supplementary Fig. S5).