FLNC knockdown in oesophageal squamous cell carcinoma cell lines reduced GTP-Rac1 and GTP-Cdc42 levels, thereby altering cell motility.28 However, in GBM cells, FLNC overexpression affected invasion but not migration, and there was no obvious change in Rho activity (Supplementary Fig. S6A). Here, RAC1 is linked to glioblastoma.