UBE2N and neurodevelopmental disorder: The conditional UBC13 knockout mouse is valuable for not only studying the effects of disturbances in cerebellar granule cell circuitry on gait and other aspects of locomotion, but given the observed motor deficits and possible alteration of emotionality in these mutant mice, it may provide an informative model for studying analogous behavioral anomalies in neurodevelopmental disorders resulting from deregulation of ubiquitin signaling such as occurs in ASD and Angelman syndrome.