MAPK8 and neoplasm: It activates different signaling pathways, such as nuclear factor kappa B (NFκB), c-jun N-terminal kinases (JNK), mitogen-activated protein kinases (MAPK), Janus kinase (JAK), serine-threonine protein kinase (Akt), activators of transcription protein (STAT), and others involved in the proliferation, apoptosis, and metastasis of tumor cells19,20.