To this end, the RIPK1D324A/D324A FADD−/− RIPK3−/− TM and FADD−/− RIPK3−/− DKO mice are comparable to wild type mice at young adult age (Supplementary Fig. S4) and develop progressive lymphadenopathy and splenomegaly, when aged, displaying the lpr-like phenotype (Fig. 6 and Supplementary Fig. S3). The gene discussed is RIPK3; the disease is Splenomegaly.