Through the Hapmap retrieval, we received two SNPS in GSPT1 and GSPT2 gene loci (rs33635 and rs974285), but found no statistical association between both GSPT1-rs33635 and GSPT2-rs974285 loci and the susceptibility of HBV infection, HBV NC, LC development from CHB, HCC development from CHB and LC. This evidence concerns the gene GSPT2 and laryngotracheoesophageal cleft.