Using in vitro and in vivo experiments, they further showed that the inhibition of MTHFD2, either by genetically knocking-down or chemically inhibition using folate analog LY345899 as an MTHFD2 inhibitor, could disturb the NADPH and redox homeostases and accelerate cell death under oxidative stress, such as hypoxia, or causing in vitro anchorage independence and in vivo impaired tumor growth and metastasis. Here, MTHFD2 is linked to neoplasm.