Even though we did not observe any pathology of Ran-GAP, ADARB2, FMRP and Pur-alpha, their levels could still have a modifying effect on disease progression of FTD, as has been shown in iPSC-derived neurons and Drosophila models [7, 13, 50, 54]. The gene discussed is FMR1; the disease is frontotemporal dementia.