In order to investigate the efficiency of different therapeutic pathway, hAMSC-SBE4-TRAIL were delivery via three main approaches including in into the same location of tumor mass (intracranial injection), into the circulatory system (intracardiac injection), or into the cerebrospinal fluid system (intrathecal injection) in the GBM bearing mice (Fig. 6a). Here, TNFSF10 is linked to glioblastoma.