In untreated patients, further contributors to mortality are complications of raised intracranial pressure as well as immune reconstitution inflammatory syndrome associated with cryptococcal meningitis and HAART [7]. Although the patient did not have a low CD4 count and the antifungal treatment was administered promptly, the combination of other poor prognostic factors could, at least in part, explain the patient’s death. This evidence concerns the gene CD4 and Cryptococcal meningitis.