Analogous to observations in humans, HFD-obese mice exhibited higher levels of leptin and resistin (Fig. 3a, b), which are associated with excess fat in humans and implicated in poorer breast cancer prognosis [74–80], as well as lower levels of adiponectin (Fig. 3c), an adipose tissue secretory protein inversely correlated with body fat and inversely associated with breast cancer risk [78, 81]. This evidence concerns the gene RETN and breast carcinoma.