To eliminate overgrowing normal organoids, Nanki et al. selected TP53 mutant, RHO-dysregulated, TGF-β-insensitive, and receptor tyrosine kinase-activated GC cells [36], and Yan et al. used Nutlin3a to enrich TP53 mutants [37] to establish GC organoid cultures, but we just cultured cells without selection because normal gastric epithelial cells were not included in PDX. Here, RHO is linked to gastric cancer.