Taken together, the twelve-downregulated proteins (Plp1, Mbp, Cnp, Mog, Mag, Sirt2, Cldn11, Enpp6, Bcas1, Rhog, Ugt8 and Gsn) and the upregulated protein (Hexb) in the corpus callosum of NPC mice were in the myelin structures or involved in the regulation of myelination, demonstrating hypomyelination in the disease. The gene discussed is ENPP6; the disease is nasopharyngeal carcinoma.