Although the protein profiles exhibited high similarities between WT and NPC mice, the expressions of 21 proteins were significantly different (the 2 isoforms of Mbp were combined in this study), in which 17 proteins were downregulated (red in Fig. 3a) and 4 proteins upregulated in NPC mice (green in Fig. 3a). Here, MBP is linked to nasopharyngeal carcinoma.