Taken together, the twelve-downregulated proteins (Plp1, Mbp, Cnp, Mog, Mag, Sirt2, Cldn11, Enpp6, Bcas1, Rhog, Ugt8 and Gsn) and the upregulated protein (Hexb) in the corpus callosum of NPC mice were in the myelin structures or involved in the regulation of myelination, demonstrating hypomyelination in the disease. Here, HEXB is linked to nasopharyngeal carcinoma.