Therefore, the aim of this observational, retrospective study was to: (1) describe the characteristics and associated disorders of patients with AAE-C1-INH, (2) assess the efficacy of pdC1-INH in the treatment of AAE-C1-INH patients (3) assess the effect of time to injection, dose and anti-C1-INH autoantibodies on pdC1-INH efficacy. The gene discussed is SERPING1; the disease is acquired angioedema.