In addition, despite development of several next-generation TKIs targeting ALK rearrangement with higher potency and greater blood-brain-barrier penetrating capacity, crizotinib remains one of the first-line treatment options for advanced ALK-positive NSCLC [15] and is widely used in situations where next-generation TKIs are not yet approved or economically inaccessible. Here, ALK is linked to non-small cell lung carcinoma.